Morfea profunda pdf file

Morphea is an autoimmune disease that causes sclerosis, or scarlike, changes to the skin. Morfeamorfea esclerodermia localizada esclerodermia circunscrita en placas 1 2. Morphea profunda involves deep subcutaneous tissue, including fascia, and there is a clinical overlap with eosinophilic fasciitis, eosinophiliamyalgia syndrome, and the spanish toxic oil syndrome. The term morphea profunda was proposed by person and su in 1981 to describe generalised inflammatory sclerosis of the panniculus or fascia. Histopathological changes in morphea and their clinical. You may already have this file even though you are getting. Gli studi epidemiologici riportano unincidenza rara che varia dallo 0,4 al 2,7 per 100. Other drugs such as intravenous immunoglobulin, infliximab, rituximab, cyclosporine and dapsone esclerodermia morfea been used in refractory cases with variable responses. Hashimoto, et tence of generalizad morphea with histological changes in. Morphea is characterized by skin thickening with increased quantities of collagen in the indurative lesion. Morphea is diagnosed based on findings of skin examination and skin biopsy. Extracorporeal photochemotherapy for generalized deep morphea. Periodic followup is necessary in morphea profunda to identify systemic.

Generalized morphea presents as four or more areas of skin and subcutaneous fibrosis. Frequent atrophy of adnexal structures, increased fibroblasts, thickening and luminal narrowing of small vessels, blunting of dermalsubcutis. Circumscribed morphea causes circular fibrosis of the skin and subcutaneous fat in one to three areas. Morphea is a form of scleroderma that is more common in women than men, in a ratio 3.

Las lesiones son mas bien difusas y poco circunscritas o lineales. Autoimmune diseases occur when the immune system, which normally protects us from bacteria, viruses, and fungi, mistakenly attacks a persons own body. It is the most common subtype in adults and is unlikely to involve the underlying muscle or bone. Morfea profunda morfea panesclerosante invalidante del nino. The histopathologic changes in morphea profunda differ from those of conventional widespread morphea because of deeper. The deep artery of the thigh branches off the femoral artery soon after its origin. The term deep morphea describes a variant of morphea localised scleroderma in which inflammation and sclerosis are found in the deep dermis, panniculus. Pdf low frequency ultrasonography in plaquetype morphea. Patients with morphea do not have raynaud phenomenon fingers turning red, white, and blue with cold exposure, redness and swelling of both hands red puffy hands, changes in the blood vessels along the nail edge nailfold capillary changes, or tightening of the skin of the fingers sclerodactyly. Extensive morphea profunda with autoantibodies and benign tumors.

View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Morfea volumen 5 numero 4 octubrediciembre 2007 dermatologia cosmetica, medica y quirurgica celular subcutaneo. Pdf key clinical message although eosinophilic fasciitis is known to be part of the deep morphea spectrum, this first report of the coexistence. The following morbidities were morfex during followup. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Dermis morfea o esclerodermia circunscrita information. Pueden causar importantes alteraciones funcionales. Here we report two cases of atrophic morphea profundus presenting.

Update on the classification and treatment of localized scleroderma. The first line contains the sequence id pdb id of the morf segment and uniprot id of the parent sequence and also the secondary structure of the morf region in the bound state. Presentations ppt, key, pdf logging in or signing up. Pdf morphea profunda is a rare skin condition of unknown etiology, involves deep subcutaneous tissue, including fascia. Mar 26, 2020 esclerodermia morfea pdf introduction scleroderma is an autoimmune, polymorphic disease, mkrfea by the presence of cutaneous sclerosis secondary to the excessive accumulation of collagen. Lesionescutaneasfundamentalesyelementosdiagnosticos. Microanatomical location of sclerosis was analyzed relative to clinical subtype. It presents with one or more hyperpigmented, shiny, smooth atrophic patches with the skin bound down to the underlying structures.

Mar 12, 2020 download free morphing per windows free morphing. Specimens from patients with morphea profunda defined as involvement of the subcutis or deeper on direct pathological examination or mriultrasound imaging of the affected area had bottom heavy or full thickness patterns of sclerosis in the dermis, p0. A variant of morphea with extensive subcutaneous involvement has been termed morphea profunda. The treatment of generalized deep morphea is challenging, and no single therapy has proven to be very effective or significantly disease modifying. Pdf granulomatous fasciitis followed by morphea profunda. Localized scleroderma also called morphea is a term encompassing a spectrum of sclerotic autoimmune diseases that primarily affect the skin, but might also involve underlying structures such as the fat, fascia, muscle, and bones. This entity is subdivided into linear scleroderma, plaque. The datasets come as fasta like text file with three lines per protein. Dec 19, 2019 esclerodermia morfea pdf phenotypes of localized scleroderma according esclerodermia morfea the pres classification. Morfea o esclerodermia localizada asocolderma revista. The term solitary morphea profunda was used by whittaker to describe a solitary fibrotic plaque on the upper trunk with histological findings of a dense, mononuclear cell infiltrate mainly in the subcutis. Thickening and hyalinization of connective tissue of deep dermis, subcutaneous fat and muscular fascia, with perivascular and focal interstitial lymphocytic and plasma cell infiltrate in subcutaneous fat.

Request pdf on apr 1, 2010, juan manuel segurapalacios and others published morfea profunda find, read and cite all the research you need on researchgate. Lesionescutaneasfundamentalesyelementosdiagnosticos090930232504p authorstream presentation. This is a pdf file of an unedited manuscript that has been accepted for. Atrophic type of morphea profundus our dermatology. Dermis morfea o esclerodermia circunscrita information on. For more information see how to search your pc for. The deep artery of the thigh, profunda femoris artery or deep femoral artery is a branch of the femoral artery that, as its name suggests, travels more deeply posteriorly than the rest of the femoral artery. Natalia rebollo dominguez, daniela gutierrez mendoza. Morphea profunda is a disorder of unknown etiology but has been described to occur following vaccination and in association with borrelia burgdorferi infection.